Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA
نویسندگان
چکیده
منابع مشابه
Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA.
Diminished immune functions and chronic inflammation are hallmarks of aging. The underlying causes are not well understood. In this investigation, we show an increased reactivity of dendritic cells (DCs) from aged subjects to self-Ags as one of the potential mechanisms contributing to age-associated inflammation. Consistent with this, DCs from aged subjects display increased reactivity to intra...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2009
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.182.2.1138